Lossy compression can eat away at the quality of your image. Photoshop recompresses a JPEG image every time you save it in JPEG format. During a single edit session, this compression won't hurt because JPEG works from the on-screen version. But if you close, reopen, and resave the image in JPEG format, degradation occurs. You may not see the results right away, but you will over time. Leave your image in either TIFF or native Photoshop file formats while editing. Then, when you're completely done editing and you need to compress the image, save the file as a JPEG at a high to maximum quality setting.
Thanks for the tip Christo....I didnt know that....
Good info. Always keep the image in native Photoshop (PSD) format until you want to export (save) it to a final version for print or the web or other purposes.
And back up your PSDs ever so often, especially if the work is important ;-)